Defining novel approaches to genome-informed, targeted therapy for osteosarcoma using patient-derived xenograft models.

I am a cancer biologist and practicing pediatric oncologist focused on basic and translational cancer research. My laboratory's disease focus includes both pediatric sarcomas and lung cancer. Our sarcoma work is focused on defining mechanisms driving osteosarcoma and Ewing sarcoma progression, metastasis and therapy resistance. We have extensive expertise in integrative genomic analysis (WGS, RNAseq, ATACseq) and functional genomic studies using CRISPR/CAS9. We use these tools to drive gene and network discovery using primary tumors, patient-derived xenograft models, and genetically engineered mouse models. I also have experience in real-world application of tumor sequencing for precision cancer medicine and I currently lead the Molecular Oncology Initiative (MOI) at UCSF.